KMID : 0370019970110000015
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Chung-Ang Journal of Pharmacal Sciences 1997 Volume.11 No. 0 p.15 ~ p.23
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The effects of Evening Primrose Oil (EPO), Vit.C and Vit.E on Never Conduction Velocity(NCV) in Streptozotocin-induced Diabetic rats
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Abstract
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The effects of evening primrose oil (EPO). Vit.C and Vit.E on nerve conduction velocity (NCV) in streptozotocin -induced diabetic rats were investigated. 5 weeks- diabetes caused 27¡¾0.5 % reduction in sciatic motor conduction velocity as compared with normal control. Dietary supplement of 5% EPO. 125mg/kg Vit.C. and lg/kg Vit.E prevented significantly the development of the motor nerve conduction velocity deficit about 21¡¾0.5, 21¡¾0.5, 26¡¾0.5% respectively. The total serum cholesterol and triglyceride were decreased by administration 5% EPO. Vit.C, and Vit.E as compared with diabetic control. However, the serum glucose was not decreased by administration 5% EPO. 125mg/kg Vit.C but the serum glucose was decreased by administration lg/kg Vit.E as compared with diabetic control.
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